Welcome to The Darfeuille Lab

The main objectives of the D-lab are the identification and characterization of small non-coding RNAs associated with the infection by the major human gastric pathogen Helicobacter pylori. We seek to understand the molecular and biochemical basis of RNA-based regulation of key genes involved in the pathogenicity and/or metabolism of this bacterium. In collaboration with RNA chemists, our group also aims at the identification of small compounds able to interfere with the biogenesis and regulation of small RNAs. We hope that our research will help to develop alternative strategies to fight against drug resistance, both, in the field of cancer as well as in bacterial infections (antibiotic resistance).

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News !

Want to identify the toxicity determinants hidden within your type I TA system? Try out our method! FASTBAC-Seq: Functional AnalysiS of Toxin-Antitoxin Systems in BACteria by Deep Sequencing  https://www.sciencedirect.com/science/article/pii/S0076687918303318...

We are pleased to share with you that our latest review article ‘Type I Toxin-Antitoxin Systems: Regulating Toxin Expression via Shine-Dalgarno Sequence Sequestration and Small RNA Binding’ is now available on the ASMscience website!  ...

We are excited to announce the ‘RNA, Bacteria, and Diseases’ Micro-symposium to be held on October 19th at the IECB, Bordeaux (France). Free registration, outstanding keynote speakers in the fields of bacterial riboregulation and pathogenesis! Looking forward to it !!...

Delphine Bronesky (PhD student, Université de Strasbourg, Architecture de l’ARN et réactivité, IBMC, under the supervision of P. Romby and I. Caldelari) has recently joined the lab ! She will start a new project in the group, that consists in turning on the expression of toxin-antitoxin......

The D-Lab is just back from the traditional  3-days Lab retreat in the Pyrénées ! A great occasion to get to know about the last and most exciting research going on in each of the teams composing this astonishing Unit ! .. and, of course, have some fun !......

  Our lastest paper is now published online in Nucleic Acids Research !   Please visit NAR Advance Access A new toxin antitoxin system was discovered in the human gastric pathogen Helicobacter pylori. This new TA system is actually conserved in many epsilon proteobacteria. It......

With 2016 coming to its end, from the D-Lab we wish you an intense New Year 2017, full of energy, creativity and vision!...

Last week our student Sara Masachis Gelo travelled to Groningen to attend the 3rd workshop of the MetaRNA ITN network. In this occasion, the fellows had the opportunity to expand their knowledge on metabolomics, metabolic fluxes and kinetic modelling guided by the coordinator, Prof. Dr.......

They didn't know it was impossible so they did it ! Mark Twain

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