The main objectives of the D-lab are the identification and characterization of small non-coding RNAs associated with the infection by the major human gastric pathogen Helicobacter pylori. We seek to understand the molecular and biochemical basis of RNA-based regulation of key genes involved in the pathogenicity and/or metabolism of this bacterium. In collaboration with RNA chemists, our group also aims at the identification of small compounds able to interfere with the biogenesis and regulation of small RNAs. We hope that our research will help to develop alternative strategies to fight against drug resistance, both, in the field of cancer as well as in bacterial infections (antibiotic resistance).
La liste des lauréats Atip-Avenir 2020 est en ligne. 👏👏👏 Félicitations aux 22 lauréats ! 👏👏👏 mais tout particulièrement à Anaïs Le Rhun, post-doctorante dans l’équipe ! Nous t’adressons toutes nos félicitations et te souhaitons le meilleur pour la suite. Source : Atip-Avenir 2020 : la liste des......
A major update has recently been released for the T1TAdb . A number of loci have been re-predicted and corrected, in particular with respect to the location and sequence of the antitoxin asRNA Source : T1TAdb: the database of Type I Toxin-Antitoxin systems...
Anthony Bugaut (CRCN, CNRS) has recently ((officially since April 1st) joined our team to start a new project for him , i.e activating toxin-antitoxin to fight antibiotic resistance. Unfortunately due to the Covid-19 crisis, he just started in May! Welcome Anthony!...
Nicolas J. Tourasse (IR INSERM) has written a clear and easy step by step protocol to run your favorite structural alignment and covariation analysis. Protocol is freely available at Bio-protocol, an online peer-reviewed protocol journal. Its mission is to make life science research more efficient and reproducible......
Congratulations Anaïs for being laureate of the FEBS Long-term Fellowship!...
We are really excited to share with you our latest contribution published at @eLife special thanks to @MasachisG and all co-authors for their great work ! https://t.co/WQEFoD42qT — D-lab (@FabienDlab) August 15, 2019...
Congratulation to Isabelle Iost for her nice story on Maturation of atypical ribosomal RNA precursors in Helicobacter pylori https://t.co/u0Buk0njk8 — D-lab (@FabienDlab) April 22, 2019...
T1TAdb ! the first database dedicated to type I toxin-antitoxin systems ! it currently contains 2065 TA loci from 671 bacterial strains and 21 TA families ! Please visit it and send us your comments ! https://t.co/s1zkGmxRrt pic.twitter.com/lZtJRVHoSk — D-lab (@FabienDlab) January 9, 2019...
Want to identify the toxicity determinants hidden within your type I TA system? Try out our method! FASTBAC-Seq: Functional AnalysiS of Toxin-Antitoxin Systems in BACteria by Deep Sequencing ...
We are pleased to share with you that our latest review article ‘Type I Toxin-Antitoxin Systems: Regulating Toxin Expression via Shine-Dalgarno Sequence Sequestration and Small RNA Binding’ is now available on the ASMscience website! ...
They didn't know it was impossible so they did it ! Mark Twain
