Welcome to The Darfeuille Lab

The main objectives of the D-lab are the identification and characterization of small non-coding RNAs associated with the infection by the major human gastric pathogen Helicobacter pylori. We seek to understand the molecular and biochemical basis of RNA-based regulation of key genes involved in the pathogenicity and/or metabolism of this bacterium. In collaboration with RNA chemists, our group also aims at the identification of small compounds able to interfere with the biogenesis and regulation of small RNAs. We hope that our research will help to develop alternative strategies to fight against drug resistance, both, in the field of cancer as well as in bacterial infections (antibiotic resistance).

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Our research

 

Our papers

 

Meet the team

 

News !

  Our lastest paper is now published online in Nucleic Acids Research !   Please visit NAR Advance Access A new toxin antitoxin system was discovered in the human gastric pathogen Helicobacter pylori. This new TA system is actually conserved in many epsilon proteobacteria. It......

With 2016 coming to its end, from the D-Lab we wish you an intense New Year 2017, full of energy, creativity and vision!...

They didn't know it was impossible so they did it ! Mark Twain

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