Welcome to The Darfeuille Lab

The main objectives of the D-lab are the identification and characterization of small non-coding RNAs associated with the infection by the major human gastric pathogen Helicobacter pylori. We seek to understand the molecular and biochemical basis of RNA-based regulation of key genes involved in the pathogenicity and/or metabolism of this bacterium. In collaboration with RNA chemists, our group also aims at the identification of small compounds able to interfere with the biogenesis and regulation of small RNAs. We hope that our research will help to develop alternative strategies to fight against drug resistance, both, in the field of cancer as well as in bacterial infections (antibiotic resistance).

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Our research


Our papers


Meet the team


News !

Last week our student Sara Masachis Gelo travelled to Groningen to attend the 3rd workshop of the MetaRNA ITN network. In this occasion, the fellows had the opportunity to expand their knowledge on metabolomics, metabolic fluxes and kinetic modelling guided by the coordinator, Prof. Dr.......

Nicolas Fix (Master MIMU, University of Bordeaux) is joigning the D-lab for a 6 month internship to defend his master degree in June 2017 ! His project will aim at developing an efficient tool to predict TA systems in bacteria. Welcome Nicolas !...

Sara Masachis Gelo (recruited in the EU Research-Training Network MetaRNA) recently joined the D-lab to start her PhD. She will engeneer RNA-based expression systems to monitor metabolic changes in living cells. Please find more infos about Sara: https://metarna.wordpress.com/2016/01/09/meet-the-fellows/  ...

They didn't know it was impossible so they did it ! Mark Twain

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